Correlation between Compaction and Dissolution of Metoprolol Tartarate Tablets Prepared by Direct Compression Using Different Polymers

The investigation is to study the effect of polymers on compressibility and release of Metoprolol Tartarate from tablet through direct compression. Tablets were prepared by direct compression by mixing with commonly used polymers, Eudragit RL-100, Chitosan, Ethyl cellulose, Hydroxyethyl cellulose and hydroxypropylmethyl cellulose K-100 in 1:1 ratio. The compressibility parameters were estimated utilizing Heckel and Kawakita equations. Compactibility, compressibility and tabletibility have been evaluated to understand the total tableting performance. A correlation has been established between 50 % drug release (t50%) and compression bn and chitosan could be utilized for sustained releasing and fast releasing agent respectively. Hydroxypropylmethyl cellulose and chitosan are suitable release retardant and fast releasing agents respectively for tablet formulation of Metoprolol Tartarate through direct compression.